Abstract Introduction Chronic rhinitis (CR) represents a widespread inflammation with a high incidence in the general population. Although it is generally considered a benign condition, CR has a relevant impact on quality of life and requires a specific treatment approach. Objective The aim of the present study was to investigate the efficacy of glycyrrhizin and mannitol intranasal treatment on chronic rhinitis using cytological analysis and subjective evaluation of symptoms. Methods A total of 55 patients suffering from chronic rhinitis were enrolled in the present study, 34 with allergic rhinitis (AR) and 21 with nonallergic rhinitis (NAR). The severity of four different nasal symptoms was determined by using a visual analogue scale (VAS). Specimens obtained by nasal scraping were collected for cytological analysis. Data were acquired before and after a 30-day treatment with glycyrrhizin and mannitol nasal spray. Statistical analyses were performed. Results The VAS scores for all four nasal symptoms considered in the present study, as well as for neutrophil cells, reduced significantly after therapy in both allergic and nonallergic patients. The number of eosinophils was not significantly lower in nonallergic patients. Conclusion A 30-day topical treatment with glycyrrhizin and mannitol may improve nasal symptoms and reduce inflammatory cells in the nasal mucosa in patients with chronic rhinitis without significant contraindications. Further studies could support our results and would better clarify all the aspects of this treatment.

Se describe la realización de una neurolisis del plexo celíaco en un paciente con neoplasma evadido de cabeza de páncreas con dolor severo, e intolerancia digestiva y mala respuesta analgésica a altas dosis de morfina. Se utilizó la vía de abordaje posterior retrocrural con control radioscópico, administrándose 12 ml de alcohol al 70% de cada lado. Durante el procedimiento se administró midazolam, fentanil y reposición con suero ringer lactato. Se observó dolor fugaz durante la administracción del neurolítico y a los pocos minutos desaparición de la sintomatología dolorosa, procediéndose al retiro gradual de la morfina. El único efecto colateral observado fue aceleración del tránsito digestivo. Fallece a los 33 días de realizada la neurolisis, analgesiado sin recibir opiacéos. Concluimos que este procedimiento es una opción eficaz en el control del dolor por neoplasma de páncreas, en los pacientes con mala respuesta a los opiáceos.

The present work describes a celiac plexus neurolysis procedure in a patient with a pancreas head neoplasm, disseminated, with severe pain and digestive intolerance, and with no good analgesia response to high doses of morphine. The posterior retrocrural technique was used, X-ray guided, administering 12ml of 70% alcohol on each side. During the procedure midazolam, fentanil and Ringer Lactate was administrated. No pain was shown during the administration of the neurolytic solution, and after few minutes the pain symptoms disappeared, proceeding to the gradual suspension of morphine. The only side effect shown was digestive transit alteration. The patient died after 33 days of neurolysis, analgesiated and not receiving opiates. We conclude that this procedure is an efficient option in the control of pain caused by pancreas neoplasm, in patients with poor response to opiates.